Resistance Management: If Every Problem is Unique, can the Answer Be the Same?

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Janet McAllister, the distinguished PhD Medical Entomologist from the CDC Arboviral Diseases Branch of the CDC’s Division of Vector-Borne Diseases, was among the notable speakers to present at the Global Mosquito Resistance Management Virtual Summit held in late March of 2022. McAllister’s objective was stressing the need for Integrated Vector Management to reduce vector resistance in local areas.

McAllister continued to explain that a single mechanism or a combination of mechanisms can be present in resistant mosquitoes, and that the first step of managing resistance is determining what kind of resistance is present in a population. She established that while the type of tests used to detect resistance is a local decision, that resultant data is critical in choosing the correct resistance management strategy.

“The development of resistance is focal and the mechanism behind that resistance can be different even to the same chemical.”

McAllister presented what she termed the three classic resistance management strategies: moderation, saturation, and multiple attack; diving deeper into available tactics and nuances of each approach. She demonstrated that while all three are sound strategies, using any of them without fully understanding the mechanisms of the resistance at hand would be a mistake. Once again, McAllister emphasized that selecting the best strategy depends on the data.