resistance

Resistance in the Limelight

Doctor Shinji Kasai’s recent publication on the combined effects of three knockdown resistance (kdr) mutations in Aedes aegypti sparked media frenzy. He demonstrated the causal relationship between specific genes & pyrethroid sensitivity in mosquitoes.

The study improved understanding of insecticide resistance evolution & opened new strategies to control mosquito populations & reduce disease spread. Kasai’s latest paper on super-insecticide-resistant dengue mosquitoes caused a stir in the media, revealing high levels of pyrethroid resistance in field populations.

Insecticide Resistance in Arthropods

Insecticide resistance is a global problem that poses mounting challenges to human health. Insects’ ability to quickly adapt to chemical interventions renders products ineffective and undermines pest management efforts in both agriculture and public health. This compromises our capacity to produce a safe and affordable food supply while impairing our ability to safeguard society against crippling or even fatal vector-borne disease.

Resisting Resistance

In biological terms, resistance can be defined as the natural ability of an organism to withstand a damaging agent or adverse condition. Animals, plants, and microbes have all demonstrated the ability to develop resistance, with either positive or negative outcomes, depending on the interaction.

It All Started with a Gift

Merck’s commitment to donate ivermectin for onchocerciasis control in the late 80s was only the beginning of the challenge to deliver the intervention to those …