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Mosquitoes that carry West Nile are becoming resistant to insecticides

John VanDenBerg suspects he was gardening when a mosquito got him.

It was September 2018, and VanDenBerg, then 67, had been feeling a little “off” for a few days, he said, like maybe he had the flu.

But one morning, as he was walking out of his Colorado home, he collapsed.

The Economics of Malaria

In the 2022 World Malaria Report, compiled by the World Health Organization (WHO), the total spend on funding the fight of malaria in 2021 was estimated at USD 3.5 billion. Over that year, the same report states that there were an estimated 247 million cases of malaria and 619,000 malaria deaths globally.

More recently, over the course of the 20th Century, malaria is believed to have claimed between 150–300 million lives. The disease is contracted predominantly in the tropical regions: sub-Saharan Africa, Asia and the Amazon basin. This is due to the prevalence of the Anopheles mosquito that transmits the disease. Poorer regions of Africa bear the vast majority of the burden. In 2021, around 95% of the diagnosed cases and deaths were on the African continent, 80% of which were children under the age of five. The disease is entirely preventable and curable with prompt diagnosis and effective methods of treatment which require sufficient investment and funding.

Deforestation’s Hidden Toll: Amplifying Disease Risk Worldwide

In the last couple of decades, the lush rainforest around the remote village of Meliandou in the heart of Guinea has become patchier. Animals, like bats, saw their habitats dwindle and in a quest for survival, they sought refuge in closer proximity to human environments, making the boundaries between species thinner. A hollowed-out tree in the middle of the village became home to a colony of bats.

About 50 meters from the same tree, in the heart of Meliandou, a two-year-old boy named Emile lived with his family. In a matter of days, Emile fell ill with an unknown virus, developed a high fever, and died. Soon the same virus, that scientists now believe Emile got from the bats, took the lives of his sister, mother, and grandmother. The village, surrounded by a ring of forest, unexpectedly became the epicenter of a devastating outbreak that would leave an indelible mark.

Aedes aegypti: Beyond the Black and White

One look at Aedes aegypti gives an immediate impression of its menacing nature. The telltale dark and white bands on the mosquito’s legs and other body parts bring a sense of foreboding and hardship. Sleek, silent, and stealthy, Ae. aegypti is the primary vector for several important, debilitating, and sometimes fatal human diseases including dengue, Zika virus, yellow fever, and chikungunya. The species is cause for mounting concern on many levels, as its biology, behavior, and ability to adapt have made Aedes aegypti one of the most pervasive and daunting public health challenges in the modern world.

The first mosquito ever associated with the spread of disease, Ae. aegypti is also the most studied of all mosquito species.1 From its humble beginnings in the African wild to a footprint that spans the globe, this durable and opportunistic insect has become a formidable opponent of vector control efforts worldwide.

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