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A Shining New Age of Vaccines
With vaccines, history repeats itself like music stuck in a loop. On the one hand, advancing technologies create vaccines against a growing list of lethal diseases and conditions. On the other hand, outrageous myths and conspiracy theories compete against science. Familiar and strong emotions run the gamut, from relief when deadly diseases like smallpox are eradicated to anger about perceived dangers to health, governmental overreach and threats to freedom of choice. While religious, commercial, pseudo-scientific and political interests cash in on the confusion, context and meaning are sometimes lost or forgotten. Telling facts apart from misinformation becomes difficult.
Understanding how vaccines are evolving can help better understand both why they are one of medical science’s supreme triumphs and also why the anti-vaccine movement continues to grow and influence so many.
Tick-ing Time Bomb: The Expanding Threat of Tick-Borne Diseases
Urbanization, resistance to pesticides, and, most critically, climate change are creating ideal conditions for global tick proliferation. As these 8-legged bloodsuckers expand their territories, the world should expect a corresponding rise in Lyme disease, spotted fever, Crimean-Congo hemorrhagic fever, tick-borne encephalitis, and other conditions that infect humans, pets, and livestock.
“This is an epidemic in slow motion,” a Centers for Disease Control (CDC) tick expert and research, biologist told the Associated Press.
Ticks live on every continent except Antarctica, and while estimates of annual tick populations vary, the scientific community agrees that their numbers are growing. Researchers also are unanimous that arachnids pose an increasing health risk as mild winters and longer summers associated with global warming kill off fewer individuals, give them longer to develop and feed, and make higher elevations and northerly latitudes that previously were too intemperate or elevated more hospitable.
Role of Social Determinants in Maternal and Child Health
About 287,000 women died during and following pregnancy and childbirth in 2020. Around 95% of these maternal deaths occurred in low and lower middle-income countries and nearly every death was preventable. Equally, children under the age of five continue to face differing chances of survival based on where they are born and raised.
A child born in sub-Saharan Africa is 11 times more likely to die in the first month of life than one born in the region of Australia and New Zealand, and a 15-year-old girl in sub-Saharan Africa is 400 times more likely to die in her lifetime due to issues related to childbirth than a 15-year-old girl living in Australia and New Zealand (with the ratio for SSA being 1 in 40, compared to ANZ being 1 in 16,000 women).
Shrinking Forests, Emerging Diseases
Dona Dora’s man is away from home a lot more these days. It didn’t used to be like that.
He leaves early, sometimes on foot, but increasingly on his bicycle, and heads into the forests surrounding Belém, the capital of Brazil’s Para province. He keeps his eyes open especially for five medicinal plants that are always in demand — sucuúba (Himatanthus sucuuba), copaíba (Copaifera spp.), andiroba (Carapa guianensis), barbatimão (Stryphnodendron spp.) and pãu d’arco (Tabebuia avellanedae).
Fifteen years earlier, he would have found all five within hours and been back for lunch, but times have changed. These days, medicinal forest plants in high demand are becoming harder to find as forests that have stood strong for millennia are cleared to make way for grazing pastures for millions of cattle, agriculture, and development.
Now, Dona Dora’s man can spend a whole day and not find more than a few plants. It might be late at night before he gets back home.
The Rise of Dengue: A Global Perspective
Around the world, dengue is considered the most common viral disease transmitted by mosquitoes that affects people. According to the World Health Organization (WHO), the disease is now endemic in more than 100 countries. In the first three months of 2024, over five million dengue cases and over 2000 dengue-related deaths were reported globally. The figures so far project that 2024 could be even worse than 2023, with the regions most seriously affected being the Americas, South-East Asia, and Western Pacific.
In the Americas, there were 6,186,805 suspected cases of dengue reported in the first 15 weeks of 2024. To put this into perspective, according to the Pan American Health Organization (PAHO), this figure represents an increase of 254% compared to the same period in 2023. Of these cases 5,928 were confirmed and classified as severe dengue.
Europe and the U.S. Battle Measles – Again
Initially, doctors in the Tuzla Canton of the Federation of Bosnia and Herzegovina thought the rash on young Imran’s* stomach could be scarlet fever. Or maybe it was Kawasaki disease. As reported by Eurosurveillance, that was in early December 2023. By Christmas, four of Imran’s preschool classmates had been admitted to the hospital with measles. By mid-January 2024, another epidemiologically linked case – again originally misdiagnosed as the much less contagious scarlet fever – presented in a neighboring canton. Two more quickly followed. Between the last week of December and the middle of February, the Balkan nation had reported 141 new measles cases.
Barts Health Trust’s Dr. David Harrington said the misdiagnoses should not be unexpected.
“Many front-line clinicians won’t have seen measles for several years,” he told Medscape UK. “So good education and training and collaboration between public health and infection specialists with those in primary and emergency care is key.”
The Economics of Resistance
It would be extremely difficult to calculate, with any high degree of accuracy, the global economic impact of insecticide resistance. For starters, we must consider that insect management plays a pivotal role in a variety of sectors – agriculture, home and garden, forestry, structural applications, and vector control. Analysis of the totality of economic impacts arising from resistance in any one of these sectors quickly becomes a complicated interplay of variables that interact within that given system.
To account for the full economic impact, one must layer in the amount being spent on insect management and how much of that investment is lost to resistance, but also the economic impact of losses to the overarching objectives of a given program.
To calculate the impact, you must first calculate what is at risk.
Beyond Salmonella: Emerging Foodborne Threats
Walkerton, a serene town in Bruce County, Ontario, with a population of under 5,000, embodies tranquil rural charm, where close-knit communities thrive amid picturesque landscapes. Here on May 15, 2000, the local public utilities commission took a routine sample of the water supply and discovered E. coli contamination. The commission didn’t notify public health officials.
In the following days, several people fell ill with bloody diarrhea. The local public utilities commission reassured officials a couple of times that the water supply was safe, even though cases kept rising. By the time health officials finally warned the community against consuming untreated tap water, over 40 individuals had already sought medical attention at the hospital.
The Walkerton E. coli outbreak that saw 2,300 people fall ill, and seven die, was the worst public health disaster involving municipal water in Canadian history.
Dr. Salim Abdulla: The Heart and Soul of Malaria Research
Dr. Salim Abdulla is a distinguished clinical epidemiologist whose remarkable career has significantly impacted the global fight against malaria and emerging pathogens. With over 20 years of experience in conducting clinical trials and groundbreaking research, he has played a pivotal role in shaping national malaria policies and leading innovations in healthcare.
Throughout his career, Dr. Abdulla has focused on evaluating and introducing critical interventions in the fight against malaria. He conducted extensive research on insecticide-treated bednets (ITNs) and artemisinin-based combination therapies, leading to important advancements in national malaria policy formulation. Notably, he is currently engaged in the evaluation of new malaria vaccines and treatments, with the goal of achieving regulatory licensure.
Malaria by the Numbers
According to the 2022 World Malaria Report, despite disruptions to prevention, diagnostic and treatment services during the pandemic, countries around the world have largely held the line against further setbacks to malaria control.
Good news:
Progress towards malaria elimination is increasing; in 2021, there were 84 malaria endemic countries compared with 108 in 2000.